A domestic research team has discovered for the짱구카지노 도메인 first time that there is a significant relationship between depression and the concentration of taurine in the hippocampus, which is responsible for memory and learning functions.
The Korea Basic Science Institute ( KBSI ) announced that the research team led by Senior Researcher Song Young-gyu of the Biochemical Analysis Team confirmed that taurine concentration was significantly reduced in the brain hippocampus of young women showing symptoms of depression and published it in the international academic journal ‘Biological Psychiatry’ in September. It was announced on the 25th.
According to the World Health Organization ( WHO ), there are approximately 260 million people suffering from depression worldwide. In Korea, women in their 20s accounted for 12.1% of the 1,000,744 patients with depression in 2022, and the rate of increase was also found to have more than doubled over the past five years.
The research team conducted a study on 76 women aged 19 to 29, along with the Korea Institute of Oriental Medicine and the research team of Professor Jin-Hoon Son of Chungnam National University. The subjects were divided into an experimental group of 36 people with depression and 40 people in the general control group, classified through tests and expert interviews, and compared. The brain was imaged using
KBSI ‘s ultra-high magnetic field 7 Tesla (T) human MRI (7T MRI ). This equipment features high signal sensitivity and high resolution, and was able to capture taurine, which has a low concentration compared to other neurometabolites and is difficult to obtain a signal from.
To identify substances closely related to depression, the research team examined 7 substances including taurine, choline, creatine, glutamine, glutamate, myo-inositol, and N-acetyl aspartate, which are present in the frontal, occipital, and hippocampus regions of women in their 20s . The concentrations of each dog’s neurometabolites were measured and compared.
As a result, the average concentration of taurine measured in the hippocampus of the depression experimental group and the general population control group was 0.91 mmol ( mM ) and 1.13mM, respectively, showing that the concentration of taurine in the hippocampus of young women with depression was about 20% lower than that of the general population. This is the first time that the relationship between neurometabolites in the hippocampus located inside the brain and depression has been revealed. Next , based on the high-resolution structural image of 7T MRI, the concentration of metabolites was accurately measured, reflecting the characteristics of brain tissue such as white matter and gray matter, which are distributed differently depending on the
individual . The research team predicted, “In the future, it will be applicable to personalized brain disease research tailored to each individual’s characteristics.”
Cho Ji-hyeon, a senior researcher in the biochemical analysis team, said, “We will contribute to the development of the pathogenesis and diagnosis of depression through research on the role of taurine in the hippocampus related to depression.”